Morpholinos: Antisense and Sensibility
نویسندگان
چکیده
منابع مشابه
Morpholinos: Antisense and Sensibility.
For over 15 years, antisense morpholino oligonucleotides (MOs) have allowed developmental biologists to make key discoveries regarding developmental mechanisms in numerous model organisms. Recently, serious concerns have been raised as to the specificity of MO effects, and it has been recommended to discontinue their usage, despite the long experience of the scientific community with the MO too...
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To understand the molecular mechanisms of development it is essential to be able to turn genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs) are very common tools used in several model organisms with which it is possible to block gene expression. Recently developed photo-activated MOs allow control over the onset of MO activity. However, deactivatio...
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Department of Chemistry, University of Philadelphia, Pennsylvania 19104, USA. E-m Department of Systems Pharmacology an School of Medicine, University of Pennsyl Hamilton Walk, Philadelphia, Pennsylvania † Electronic supplementary information characterization data for RuBEP, Ru– injection protocols, and oligo sequen crystallographic data in CIF or o 10.1039/c4sc03990d Cite this: Chem. Sci., 201...
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F or decades, researchers have built computer models of molecular interactions to predict properties of new molecules (1). These models take the form of potential functions, equations that can be used predict the molecular energy of interaction. Potential functions have very broad applications. Other than ab initio quantum mechanics-based approaches (2), all simulations studies rely on some sor...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2015
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2015.09.017